Associate Professor of Biology

Office: 205-4 Hayes Biology Building

Phone: 409-880-8259

Email: ian.lian@lamar.edu

Education:

• 2007 Ph.D. in Bioengineering. University of California, San Diego
• 2004 M.S. in Bioengineering, University of California, San Diego
• 1999 B.S. in Bioengineering & Engineering Physics, University of California, San Diego

Courses taught:

• Anatomy and Physiology I (BIOL 2401)
• Honors Seminar in Stem Cell Biology (HNRS 3161)
• Biomedical Technology Applications (BIOL 4401/5401)
• Cell Biology/Histology (BIOL 4470/5475)
• Graduate Seminar (BIOL 5110)

Research Interests:

• Cancer research
• Stem Cell Biology
• Bioengineering
• Medical technology applications

Selected Peer-Reviewed Research Publications:

Xinyu Chen,  Lauren Waller,  Jiajie Chen,  Rui Tang, Zunming Zhang, Ivan Gagne, Bien Gutierrez, Sung Hwan Cho, Chi-Yang Tseng, Ian Y. Lian, and Yu-Hwa Lo “Label-free image-encoded microfluidic cell sorter with a scanning Bessel beam” APL Photonics 2021, 6, 076101

Jingqiang Li, Sithara S Wijeratne, Tyler E Nelson, Tsung-Cheng Lin, Xin He, Xuewen Feng, Nicolas Nikoloutsos, Raymond Fang, Kevin Jiang, Ian Lian, Ching-Hwa Kiang “Dependence of Membrane Tether Strength on Substrate Rigidity Probed by Single-Cell Force Spectroscopy” The journal of physical chemistry letters, 2020, 11 (10), 4173-4178 

Tsung-Cheng Lin, Jingqiang Li, Sithara S Wijeratne, Xin He, Xuewen Feng, Nicolas Nikoloutsos, Raymond Fang, Kevin Jiang, Ian Y Lian, Ching-Hwa Kiang “Quantifying Substrate Rigidity Effects on Cancer Cell Mechanics using Single Cell Force Spectroscopy” Biophysical Journal 2020, 118 (3), 604a 

Xinyu Chen, Yi Gu, Jiajie Chen, Chang-Hung Lee, Ivan Gagne, Rui Tang, Lauren Waller, Zunming Zhang, Alex Ce Zhang, Yuanyuan Han, Weian Wang, Ian Y Lian, Sung Hwan Cho, Yu-Hwa Lo "Image-guided cell sorting using fast scanning lasers” APL Photonics 2020, 5 (4), 040801 

Sakshi Yadav, Semih Gulec, Rafael Tadmor, Ian Lian "A Novel Technique Enables Quantifying the Molecular Interaction of Solvents with Biological Tissues" Scientific Reports 2019, 9 (1), 9319

CW Yao, D Sebastian, I Lian, Ö Günaydın-Şen, R Clarke, K Clayton, Chiou-Yun Chen, Krishna Kharel, Yanyu Chen, Qibo Li “Corrosion Resistance and Durability of Superhydrophobic Copper Surface in Corrosive NaCl Aqueous Solution” Coatings, 2018, 8 (2), 70

Wu TF, Chen YC, Wang WC, Kucknoor AS, Lin J, Lo YH and Lian I “Rapid Pathogen Detection in Water Samples on Mobile Electronics” Sensors, 2017, 17 (6), 1348

Zhang T, Wei T, Han Y, Ma H, Samieegohar M, Chen PW, Lian I and Lo YH “Protein–Ligand Interaction detection with a Novel Method of Transient Induced Molecular Electronic Spectroscopy (TIMES): Experimental and Theoretical Studies**” ACS Cent. Sci., 2016, 2 (11), pp 834–842

Chiu YJ, Cai W, Shih YR, Lian I and Lo YH “A Single‐Cell Assay for Time Lapse Studies of Exosome Secretion and Cell Behaviors” SmaLL, 2016, 12(27), 3658-3666

Dai J, Chiu YJ, Lian I, Wu TF, Yang K, Lo YH “A multi-channel clogging-resistant lab on a chip cell counter and analyzer” Journal of Micromechanics and Microengineering, 2016, 26 (2), 025007

Yen T, Zhang T, Chen PW, Ku TH, Chiu YJ, Lian I and Lo YH “Self-Assembled Pico-Liter Droplet Microarray for Ultrasensitive Nucleic Acid Quantification” ACS Nano, 2015, 9 (11), 10655-10663

Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M “A gp130-Src-YAP Module Links Intestinal Inflammation to Epithelial Regeneration” Nature, 2015 519, 57–62. 

W Qiao, T Zhang , T Yen , TH Ku, J Song, I Lian and YH Lo. “Oil-Encapsulated Nanodroplet Array for Bio-molecular Detection”. Ann Biomed Eng. 2014 Sep;42(9): 1932-41

FX Yu , B Zhao, N Panupinthu, JL Jewell, I Lian, LH Wang, J Zhao, H Yuan, K Tumaneng, GB Mills and KL Guan. “Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling”. Cell 2012 Aug 17, 150(3): 780-791

I Lian, JM Kim, H Okazawa, J Zhao, B Zhao, J Yu, A Chinnaiyan, M Israel, L Goldstein, R Abujarour, S Ding and KL Guan. “The role of YAP transcription co-activator in regulating stem cells self-renewal and differentiation”. Gene & Dev. 2010 June 1, 24: 1106-1118.

W Yao, I Lian, J Nathanson and LA Sung. “Mouse Erythrocyte Tropomodulin in the Brain Reported by lacZ Knocked-in Downstream from the E1 Promoter”. Gene Expression Patterns. 2007 Dec;8(1):36-46.

Wu CC, Li YS, Haga JH, Wang N, Lian IY, Su FC, Usami S, Chien S. Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow. J Cell Biochem. 2006 Jun 1;98(3):632-41.

S Heydarkhan-Hagvall, S Chien, S Nelander, YC Li, S Yuan, J Lao, JH Haga, I Lian, P Nguyen, B Risberg and YS Li: “DNA Microarray Study on Gene Expression Profiles in Co-cultured Endothelial and Smooth Muscle cells in Response to 4- and 24-hour Shear Stress”. Molecular and Cellular Biochemistry, 2006 281:1-15.

KM Lin, B Lin, I Lian, R Mestril, and WH. Dillmann: “Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation”. Circulation 103: 2001 1787-1792